Identifying foldable regions in protein sequence from the hydrophobic signal
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چکیده
منابع مشابه
Identifying foldable regions in protein sequence from the hydrophobic signal
Structural genomics initiatives aim to elucidate representative 3D structures for the majority of protein families over the next decade, but many obstacles must be overcome. The correct design of constructs is extremely important since many proteins will be too large or contain unstructured regions and will not be amenable to crystallization. It is therefore essential to identify regions in pro...
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To find the native conformation (fold), proteins sample a subspace that is typically hundreds of orders of magnitude smaller than their full conformational space. Whether such fast folding is intrinsic or the result of natural selection, and what is the longest foldable protein, are open questions. Here, we derive the average conformational degeneracy of a lattice polypeptide chain in water and...
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MOTIVATION We consider the problem of identifying low-complexity regions (LCRs) in a protein sequence. LCRs are regions of biased composition, normally consisting of different kinds of repeats. RESULTS We define new complexity measures to compute the complexity of a sequence based on a given scoring matrix, such as BLOSUM 62. Our complexity measures also consider the order of amino acids in t...
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Background Oocyte maturity includes nuclear and cytoplasmic maturity, both of which are important for embryo fertilization. The development of oocyte is not limited to the period of follicular growth, and starts from the embryonic period and continues throughout life. In this study, for the purpose of evaluating the effect of the FSH hormone on the expression of genes, GEO access codes for this...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2007
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkm1070